Journal: bioRxiv
Article Title: Paresthesia during spinal cord stimulation depends on synchrony of dorsal column axon activation
doi: 10.1101/2023.01.10.523167
Figure Lengend Snippet: Multielectrode arrays (MEAs) were implanted into L4 DRG to record spikes conducted antidromically from the DC stimulation site (see ). Whereas stimulus artifacts and ECAPs were recorded on multiple contact, single-unit activity was detected exclusively by a single contact (presumably the one closest to the activated unit). Subtracting signals recorded from different electrodes (with similarly sized artifacts and ECAPs) yielded clean single-unit recordings, from which spikes were then sorted. (A) During c-SCS, ECAPs and single-unit spikes occur between artifacts, but the subtraction step nonetheless helps separate single-units spikes from ECAPs since they invariable overlap during c-SCS. See also . (B) During kf-SCS, single-unit spikes occur amidst artifacts and are difficult to sort without the subtraction step. On the other hand, ECAPs become small and irregular during kf-SCS and do not, therefore, obscure single-unit spikes.
Article Snippet: A multielectrode array (MEA) with 16 recording sites (A4 type, NeuroNexus) was implanted in the DRG.
Techniques: Activity Assay